Iluvien®

For patients with non-infectious uveitis or diabetic macular oedema affecting the back portion of eye.

What is Iluvien® and how can it help?

Iluvien® is a tiny, sustained-release implant that delivers a corticosteroid medication called fluocinolone acetonide directly into the eye. It is designed to:

  • Prevent relapse in recurrent non-infectious uveitis affecting the posterior segment: an inflammatory condition of the eye that can cause vision loss.
  • Treat diabetic macular oedema (DMO): a condition where fluid accumulates in the macula, leading to vision loss.

The implant releases medication continuously for up to 36 months, helping to reduce inflammation, decrease swelling, and improve or stabilise vision.

How is Iluvien® administered?

Iluvien® is administered as an intravitreal injection, meaning it is injected directly into the vitreous humor (the gel-like substance inside the eye). The procedure is performed in a clinical setting under sterile conditions. Local anaesthesia is applied to minimise discomfort. The implant is delivered using a specially designed applicator with a fine needle, ensuring precise placement within the eye.

What are the potential benefits?

  • Long-lasting treatment: One implant can provide therapeutic effects for up to 3 years.
  • Improved vision: Many patients experience stabilisation or improvement in vision.
  • Reduced treatment burden: Fewer clinic visits and interventions compared to other treatments.

Clinical studies have shown that Iluvien® can lead to sustained improvements in visual acuity and a significant reduction in retinal thickness.

What are the possible side effects?

As with any medical procedure, there are potential risks and side effects:

Very common but treatable (more than 1 in 10 people):

  • Cataract formation
  • Increased intraocular pressure (IOP)

Common and usually temporary (up to 1 in 10 people):

  • Eye pain or discomfort
  • Blurred vision
  • Floaters
  • Eye inflammation or redness

Less common but serious (up to 1 in 1,000):

  • Retinal detachment
  • Endophthalmitis (severe eye infection)

Patients should be monitored regularly for any changes in vision or eye health.

Aftercare and follow-up

You should use any prescribed eye drops as directed and avoid rubbing your eye. Attend regular eye check-ups to monitor intraocular pressure and implant effectiveness. If you develop sudden pain and persistently blurred vision, please attend your nearest urgent eye care unit.

Important safety information

Patients with the following should not have this treatment:

  • Active or suspected eye infections
  • Uncontrolled Glaucoma
  • Known hypersensitivity to fluocinolone acetonide or any implant components

Other factors to consider before proceeding with treatment: 

  • Patients without an intact posterior lens capsule may be at risk for implant migration
  • Patients should have tolerated prior corticosteroids without uncontrollable IOP rise

Always inform your eye specialist about your full medical history before receiving Iluvien®.

Review date: June 2028